Revisiting ameloblastoma through molecular and developmental biology aspects
안서영, 김승현, 안창현, 김재영,
소속 상세정보
안서영 ( An Seo-Young ) - Kyungpook National University School of Dentistry Department of Oral and Maxillofacial Radiology
김승현 ( Kim Sung-Hyun ) - Kyungpook National University Center for Laboratory Animal Resources
안창현 ( An Chang-Hyeon ) - Kyungpook National University School of Dentistry Department of Oral and Maxillofacial Radiology
김재영 ( Kim Jae-Young ) - Kyungpook National University School of Dentistry Department of Biochemistry
KMID : 0353420160400030164
Abstract
Ameloblastoma, is the most common, aggressive, and clinically significant odontogenic tumour, which is known to arise from odontogenic enamel epithelium and ectomesenchyme. Currently, there are no appropriate treatment methods and drugs except for surgical operation for treating ameloblastoma. In this manuscript, we revisit the concept of ameloblastoma through molecular and developmental biology to suggest new conceptual approaches based on the principal pathological elucidation with drug repositioning and phytochemistry. Overall, to understand and treat ameloblastoma, it is necessary that experimental model systems for precise functional evaluation of drugs and compounds with molecular and developmental biology approaches should be established.
키워드
Ameloblastoma; Drug repositioning; Growth and development; Phytochemicals
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